Reaction: Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
- in pathway: Biosynthesis of maresin-like SPMs
An unidentified hydroperoxy reductase reduces 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) to form 14(S)-hydroxy-docosahexaenoic acid (14(S)-HDHA), the precursor for the formation of maresin-like mediator Mar-L1 (Hong et al. 2014) and 14(S),21-dihydroxy-docosahexaenoic acids (Lu et al. 2010).
Reaction - small molecule participants:
14(S)-HDHA [cytosol]
14(S)-Hp-DHA [cytosol]
Reactome.org reaction link: R-HSA-9027033
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Reaction input - small molecules:
(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoic acid
Reaction output - small molecules:
(14S)-HDoHE
Reactome.org link: R-HSA-9027033