Reaction: ALOX5 oxidises EPA to 5-HEPE
- in pathway: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of eicosapentaenoic acid (EPA) to 5-hydroxy-eicosapentaenoic acid (5-HEPE) (Cipollina et al. 2014, Powell et al. 1995). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 5-oxo-EPA and its hydroxy precursor 5-HEPE, demonstrating that ALOX5 mediates the first step in 5-oxo-EPA biosynthesis (Cipollina et al. 2014).
Reaction - small molecule participants:
5-HEPE [cytosol]
EPA [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9027628
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Reaction input - small molecules:
all-cis-5,8,11,14,17-icosapentaenoic acid
dioxygen
Reaction output - small molecules:
5-HEPE
Reactome.org link: R-HSA-9027628