Reaction: ALOX5 oxidises DPAn-3 to 7-HDPAn-3
- in pathway: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of ω-3 docosapentaenoic acid (DPAn-3) to 7-hydroxy-ω-3-docosapentaenoic acid (7-HDPAn-3) (Cipollina et al. 2014). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 7-oxo-DPAn-3 and its hydroxy precursor 7-HDPAn-3, demonstrating that ALOX5 mediates the first step in 7-oxo-DPAn-3 biosynthesis (Cipollina et al. 2014).
Reaction - small molecule participants:
7-HDPAn-3 [cytosol]
DPAn-3 [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9027633
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Reaction input - small molecules:
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate
dioxygen
Reaction output - small molecules:
(8E,10Z,13Z,16Z,19Z)-7-hydroxydocosapentaenoic acid
Reactome.org link: R-HSA-9027633