Meta-Biol

• Pathways

In the absence of aspirin, dimeric cyclooxygenase 2 (PTGS2 dimer aka COX2) located on the ER membrane can mediate the oxidation of eicosapentaenoic acid (EPA) to prostaglandin D3 (PGD3) in activated macrophages (Serhan et al. 2002, Groeger et al. 2010, Wada et al. 2007). It is likely that EPA-derived oxo-derivatives are formed in the same way as demonstrated by Fitzpatrick et al. (Fitzpatrick et al. 1983, Shibata et al. 2002). EPA supplementation to mice resulted in enhanced endogenous production of 15-deoxy-PGJ3 (15d-PGJ3), the final deoxy-product of EPA (Lefils-Lacourtablaise et al. 2013).