Reaction: PGJ3 isomerises to δ12-PGJ3
- in pathway: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
It is proposed that prostaglandin J3 (PGJ3) isomerises to prostaglandin δ12-PGJ3 (δ12-PGJ3) (Fitzpatrick et al. 1983, Shibata et al. 2002). EPA supplementation to mice resulted in enhanced endogenous production of δ12-PGJ3, which was found to possess chemoprotective activity against myleoid leukemia, ablating leukemia stem cells in mice (Hedge et al. 2011, Finch et al. 2015).
Reaction - small molecule participants:
δ12-PGJ3 [cytosol]
PGJ3 [cytosol]
Reactome.org reaction link: R-HSA-9028263
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Reaction input - small molecules:
prostaglandin J3
Reaction output - small molecules:
Delta(12)-prostaglandin J3
Reactome.org link: R-HSA-9028263