Reaction: PGH3 spontaneously dehydrates to PGJ3
- in pathway: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
It is proposed that EPA-derived prostaglandin H3 (PGH3) undergoes nonenzymatic dehydration to form prostaglandin J3 (PGJ3) (Fitzpatrick et al. 1983, Shibata et al. 2002). EPA supplementation to mice resulted in enhanced endogenous production of 15-deoxy-PGJ3 (15d-PGJ3), the final deoxy-product of EPA (Lefils-Lacourtablaise et al. 2013).
Reaction - small molecule participants:
PGJ3 [cytosol]
H2O [cytosol]
PGH3 [cytosol]
Reactome.org reaction link: R-HSA-9028273
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Reaction input - small molecules:
prostaglandin H3
Reaction output - small molecules:
prostaglandin J3
water
Reactome.org link: R-HSA-9028273