Reaction: LTA4 translocates from neutrophil cytosol to platelet cytosol
- in pathway: Synthesis of Lipoxins (LX)
Leukotriene A4 (LTA4), produced by 5-lipoxygenase (ALOX5) in neutrophils, can be taken up by platelets where it is acted upon by 12-lipoxygenase (ALOX12) to form lipoxins (Samuelsson et al. 1987). The mechanism of translocation is unknown.
Reaction - small molecule participants:
LTA4 [cytosol]
LTA4 [cytosol]
Reactome.org reaction link: R-HSA-9032036
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Reaction input - small molecules:
leukotriene A4
Reaction output - small molecules:
leukotriene A4
Reactome.org link: R-HSA-9032036