Reaction: 5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region
- in pathway: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
To produce their pro-resolving effects, 5-oxo-EPA and 15d-PGJ3 are released into the exudate of local inflammation sites (Cipollina 2015). The mechanism of translocation is unknown.
Reaction - small molecule participants:
5-oxo-EPA [extracellular region]
15d-PGJ3 [extracellular region]
15d-PGJ3 [cytosol]
5-oxo-EPA [cytosol]
Reactome.org reaction link: R-HSA-9032327
======
Reaction input - small molecules:
15-deoxy-Delta(12,14)-prostaglandin J3
(6E,8Z,11Z,14Z,17Z)-5-oxoicosapentaenoic acid
Reaction output - small molecules:
(6E,8Z,11Z,14Z,17Z)-5-oxoicosapentaenoic acid
15-deoxy-Delta(12,14)-prostaglandin J3
Reactome.org link: R-HSA-9032327