Reaction: NTRK2 phosphorylates FRS3
- in pathway: Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 (TRKB) receptor phosphorylates FRS3 (also known as FRS2beta or STN2). Downstream of NTRK1 (TRKA)-mediated recruitment and phosphorylation, phosphorylated FRS3 binds to GRB2, SHP2 (PTPN11) and CKS proteins (CKS1, also known as CKS1B, and CKS2). FRS3 binding to GRB2, PTPN11 and CKSs has not been examined in the context of NTRK2 signaling (Dixon et al. 2006).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9032426
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9032426