Reaction: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin
- in pathway: Peroxisomal protein import
The deubiquitinating enzyme USP9X hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5S (inferred from the large isoform of PEX5L in Grou et al. 2012). The thioester bond is unstable and appears also to be spontaneously disrupted by nucleophilic attack of small metabolites such as reduced glutathione (Grou et al. 2009).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9033478
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9033478