Reaction: PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12
- in pathway: Peroxisomal protein import
Ubiquitinated PEX5 isoform S or isoform L (Ub:PEX5S,L) is released from the peroxisomal membrane and interaction with the Docking and Translocation Module by PEX1:PEX6:PEX26:ZFAND6 (the peroxisomal AAA ATPase complex, receptor export module) (Tamura et al. 2014, Law et al. 2017, also inferred from yeast homologs). PEX1 and PEX6 form a cytosolic hexameric ring that is anchored to the peroxisomal membrane by PEX26. Hydrolysis of ATP by PEX1 and PEX6 appears to cause a conformational change in PEX1:PEX6:PEX26:ZFAND6 that releases Ub:PEX5S,L from the peroxisomal membrane and into the cytosol (reviewed in Saffert et al. 2017).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9033505
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9033505