Reaction: TYSND1 cleaves HSD17B4
- in pathway: TYSND1 cleaves peroxisomal proteins
The trypsin-like serine-type endopeptidase TYSND1 cleaves HSD17B4 (Peroxisomal multifunctional enzyme type 2, MFP-2) between amino acid residues 311 and 312, yielding HSD17B4(1-311) and HSD17B4(312-736) (Okumoto et al. 2011, also inferred from mouse homologs). HSD17B4(1-311) dehydrogenates 3-hydroxyacyl-CoA; HSD17B4(312-736) acts as an enoyl-CoA hydratase (Jiang et al. 1997, reviewed in Huyghe et al. 2006). (In vitro, HSD17B4(312-736) facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes.) The uncleaved protein (HSD17B4) also catalyzes these reactions.
Reaction - small molecule participants:
H2O [peroxisomal matrix]
Reactome.org reaction link: R-HSA-9033530
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9033530