Reaction: NTRK3 phosphorylates PLCG1
- in pathway: Activated NTRK3 signals through PLCG1
Kinase activity of NTRK3 (TRKC) is needed for tyrosine phosphorylation and activation of PLCG1 in response to NTF3 (NT-3) (Guiton et al. 1995, Marsh and Palfrey 1996). NTRK3-mediated phosphorylation sites on PLCG1 have not been determined but are predicted to involve four tyrosine residues whose phosphorylation is known to be required for the phospholipase activity of PLCG1: Y472, Y771, Y783 and Y1253.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9034814
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9034814