Reaction: CysS248-MPST:TXN2 dissociates
- in pathway: Degradation of cysteine and homocysteine
A polysulfur chain may be produced at the catalytic site of CysS248-MPST. H2Sn is released after CysS248-MPST binds mitochondrial thioredoxin (TXN2) (Smeets et al. 2005, Yadav et al. 2013, Holzerova et al. 2016). The length of the sulfur chain released from MPST may vary depending on the availability of thioredoxin (Kimura 2016). When the interaction between MPST and thioredoxin is strong, the shorter form H2S can be released. Thioredoxin is now in the oxidised, disulfide form (HC-TXN2) and can be reduced by thioredoxin reductase in the presence of NADPH (Smeets et al. 2005, Yadav et al. 2013).
Reaction - small molecule participants:
H2S [mitochondrial matrix]
Reactome.org reaction link: R-HSA-9035484
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Reaction input - small molecules:
Reaction output - small molecules:
hydrosulfide
Reactome.org link: R-HSA-9035484