Reaction: GPER:Heterotrimeric G-protein Gs binds ESTG
- in pathway: GPER1 signaling
GPER1 (G-protein coupled estrogen receptor 1) is an estradiol-binding member of the G-protein coupled receptor family that stimulates rapid non-genomic signaling upon ligand binding (reviewed in Gaudet et al, 2015). Direct binding of E2 to GPER1 remains somewhat controversial, however, with some studies showing high affinity binding of E2 to plasma membranes in a GPER1-transfection dependent manner, and other studies refuting this assertion (Thomas et al, 2005; Revankar et al, 2005; Thomas et al, 2010; Otto et al, 2008; Pedram et al, 2006). In addition to plasma membrane signaling, intracellular E2- and GPER-mediated signaling has also been observed in the endoplasmic reticulum (Revankar et al, 2005).
Inactive GPER1 is associated with G alpha s (Filardo et al, 2007). Estrogen stimulation promotes the dissociation of the G protein subunits and initiates downstream signaling through cAMP, MAPK and PI3K pathways, among others (Filardo et al, 2000; Filardo et al, 2002; Tran et al, 2016; reviewed in Gaudet et al, 2015; Filardo, 2018).
Inactive GPER1 is associated with G alpha s (Filardo et al, 2007). Estrogen stimulation promotes the dissociation of the G protein subunits and initiates downstream signaling through cAMP, MAPK and PI3K pathways, among others (Filardo et al, 2000; Filardo et al, 2002; Tran et al, 2016; reviewed in Gaudet et al, 2015; Filardo, 2018).
Reaction - small molecule participants:
ESTG [extracellular region]
Reactome.org reaction link: R-HSA-9036307
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Reaction input - small molecules:
estrogen
Reaction output - small molecules:
Reactome.org link: R-HSA-9036307