Reaction: Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG
- in pathway: Estrogen-dependent gene expression
In addition to being a target of estrogen-dependent transcription, the progesterone receptor (PGR) interacts directly with ER alpha after stimulation with progesterone and modulates ESR1:ESTG binding (Ballare et al, 2003; Mohammed et al, 2015). Progesterone stimulation under estrogen-rich conditions promotes the release of PGR from the chaperone complex to facilitate interaction with ESR1 (Mohammed et al, 2015; reviewed in ).
Reaction - small molecule participants:
Pi [nucleoplasm]
ADP [nucleoplasm]
Reactome.org reaction link: R-HSA-9038161
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-9038161