Reaction: GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins
- in pathway: O-linked glycosylation of mucins
The human gene GCNT encodes beta-1,6-N-acetylglucosaminyltransferase which mediates core 2 O-glycan branching by the addition of N-acetylgalactosamine, an important step in mucin-type biosynthesis. There are 3 defined members in humans, 1, 3 and 4 (Bierhuizen and Fukuda, 1992; Yeh et al, 1999; Schwientek et al, 2000). Two members (6 and 7) may be part of the family based on sequence similarity.
Reaction - small molecule participants:
UDP [Golgi lumen]
UDP-GlcNAc [Golgi lumen]
Reactome.org reaction link: R-HSA-914012
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Reaction input - small molecules:
UDP-N-acetyl-alpha-D-glucosamine(2-)
Reaction output - small molecules:
UDP(3-)
Reactome.org link: R-HSA-914012