Reaction: CYBRD1:Heme reduces Fe3+ to Fe2+
- in pathway: Iron uptake and transport
Cytochrome b reductase 1 not only reduces ferrous iron in the brush-border membrane but also in the airways. It is upregulated on iron starvation. However, its electron donor molecule is still unknown (Oakhill et al, 2007; Turi et al, 2006).
Reaction - small molecule participants:
Fe2+ [extracellular region]
e- [extracellular region]
Fe3+ [extracellular region]
Reactome.org reaction link: R-HSA-917805
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Reaction input - small molecules:
electron
iron(3+)
Reaction output - small molecules:
iron(2+)
Reactome.org link: R-HSA-917805