Reaction: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+
- in pathway: Iron uptake and transport
In tissues other than the duodenum, ceruloplasmin (CP), in complex with SLC40A1 and 6 copper ions, oxidises ferrous iron (Fe2+) to ferric iron (Fe3+) after it is exported from the cell (Sato et al. 1990).
Reaction - small molecule participants:
H2O [extracellular region]
Fe3+ [extracellular region]
H+ [extracellular region]
Fe2+ [extracellular region]
O2 [extracellular region]
Reactome.org reaction link: R-HSA-917891
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Reaction input - small molecules:
hydron
iron(2+)
dioxygen
Reaction output - small molecules:
water
iron(3+)
Reactome.org link: R-HSA-917891