Reaction: ATP12A:ATP4B exchanges K+ for H+
- in pathway: Ion transport by P-type ATPases
The potassium-transporting ATPase heterodimer comprising of catalytic alpha and stabilising beta chains (ATP12A:ATP4B), catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. The human gene ATP12A encodes the catalytic alpha subunit (Grishin et al. 1994). One human gene encodes the beta subunit, ATP4B (Ma et al. 1991). ATP12A is responsible for potassium absorption in various tissues.
Reaction - small molecule participants:
H+ [extracellular region]
K+ [cytosol]
Pi [cytosol]
ADP [cytosol]
K+ [extracellular region]
H2O [cytosol]
H+ [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-937311
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Reaction input - small molecules:
potassium(1+)
water
hydron
ATP(4-)
Reaction output - small molecules:
hydron
potassium(1+)
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-937311