Reaction: Exchange of oxygen with sulfur in MoCo
- in pathway: Molybdenum cofactor biosynthesis
While the biosynthesis of the molybdenum cofactor for sulfite oxidase is finished after molybdenum ion insertion, human xanthine oxidase and aldehyde oxidase will only show activity with this cofactor when one of the oxygens bound to molybdenum is replaced with sulfur. The exchange is catalyzed by the MOCOS cysteine desulfurase (Ichida et al, 2001).
Reaction - small molecule participants:
sulfurated MoCo [cytosol]
L-Ala [cytosol]
MoCo [cytosol]
L-Cys [cytosol]
Reactome.org reaction link: R-HSA-947499
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Reaction input - small molecules:
molybdopterin cofactor
L-cysteine zwitterion
Reaction output - small molecules:
sulfurated eukaryotic molybdenum cofactor(2-)
L-alanine zwitterion
Reactome.org link: R-HSA-947499