Reaction: Molybdenum ion transfer onto molybdopterin
- in pathway: Molybdenum cofactor biosynthesis
Gephyrin, which stabilizes receptors on neuronal membranes, also catalyzes the transfer of a molybdenum ion onto the cofactor. The mechanism was elucidated in plants but, as the pathway is highly conserved, human gephyrin can complement missing plant proteins. Doubts remain about the actual molybdenum donor, probably molybdate, and whether a copper ion is possibly bound and removed (Stallmeyer et al, 1999).
Reaction - small molecule participants:
PPi [cytosol]
MoCo [cytosol]
AMP [cytosol]
H2O [cytosol]
ATP [cytosol]
MoO4(2-) [cytosol]
MPT [cytosol]
Reactome.org reaction link: R-HSA-947531
======
Reaction input - small molecules:
water
ATP(4-)
molybdate
molybdopterin(3-)
Reaction output - small molecules:
diphosphate(3-)
molybdopterin cofactor
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-947531