Reaction: FUT2 transfers Fuc to LeA to form LeB
- in pathway: Lewis blood group biosynthesis
The FUT2 gene (originally named the Se gene) expresses galactoside 2-alpha-L-fucosyltransferase 2 present on the Golgi membrane. FUT2 catalyses the α1,2 addition of fucose (Fuc) to Type 1 and Type 2 oligosaccharide chains, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the terminal galactose (Gal) of the Lewis A antigen (LeA) in an α1,2 linkage forms the Lewis B antigen (LeB) (Kelly et al. 1995, Koda et al. 1997). LeB is found only in secretors in around 80% of Europeans. LeB is only formed when an individual inherits both FUT3 (Le) and FUT2 (Se) genes and around 80% of individuals inherit FUT2.
Reaction - small molecule participants:
GDP [Golgi lumen]
LeB [Golgi lumen]
LeA [Golgi lumen]
GDP-Fuc [Golgi lumen]
Reactome.org reaction link: R-HSA-9603982
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Reaction input - small molecules:
alpha-L-Fucp-(1->4)-[beta-D-Galp-(1->3)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glcp
GDP-L-fucose
Reaction output - small molecules:
GDP(3-)
alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcNAc
Reactome.org link: R-HSA-9603982