Reaction: FUT2 transfers Fuc to LeX to form LeY
- in pathway: Lewis blood group biosynthesis
The FUT2 gene (originally named the Se gene) expresses galactoside 2-alpha-L-fucosyltransferase 2 present on the Golgi membrane. FUT2 catalyses the α1,2 addition of fucose (Fuc) to Type 1 and Type 2 oligosaccharide chains, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the terminal galactose (Gal) of the Lewis X antigen (LeX) in an α1,2 linkage forms the Lewis Y antigen (LeY) (Kelly et al. 1995, Koda et al. 1997).
Reaction - small molecule participants:
GDP [Golgi lumen]
LeY [Golgi lumen]
LeX [Golgi lumen]
GDP-Fuc [Golgi lumen]
Reactome.org reaction link: R-HSA-9603983
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Reaction input - small molecules:
Lewis X antigen
GDP-L-fucose
Reaction output - small molecules:
GDP(3-)
Lewis Y antigen
Reactome.org link: R-HSA-9603983