Reaction: FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX
- in pathway: Lewis blood group biosynthesis
Analogous to FUT3 adding fucose to Type 1 chains to form LeA, alpha-(1,3)-fucosyltransferases 4, 5 and 9 (FUT4,5,9), resident on the Golgi membrane, mediate the transfer of fucose (Fuc) to Type 2 oligosaccharide chains in an α1,3 linkage to form the Lewis X antigen (LeX) (Goelz et al. 1990, Lowe et al. 1991, Weston et al. 1992, Toivonen et al. 2002). FUT10 and FUT11 also exhibit α1,3 fucosyltransferase activity (Mollicone et al. 2009).
Reaction - small molecule participants:
LeX [Golgi lumen]
GDP [Golgi lumen]
Type 2 chain [Golgi lumen]
GDP-Fuc [Golgi lumen]
Reactome.org reaction link: R-HSA-9603984
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Reaction input - small molecules:
alpha-D-Gal-(1->3)-alpha-D-GlcNAc-(1->4)-D-Gal-yl group
GDP-L-fucose
Reaction output - small molecules:
Lewis X antigen
GDP(3-)
Reactome.org link: R-HSA-9603984