Reaction: B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain
- in pathway: Lewis blood group biosynthesis
The family of beta-1,3-galactosyltransferases (B3GALTs) transfer galactose (Gal) from UDP-alpha-D-galactose (UDP-Gal) to the β1,3 position of substrates with a terminal beta-N-acetylglucosamine (β-GlcNAc) residue. B3GALTs are involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Here, five members of this family (B3GALT1-5) can mediate the transfer of Gal to GlcNAc-β1,3-Gal-R, the precursor to blood group Type 1 oligosaccharide chains found in bodily secretions (Amado et al. 1998, Isshiki et al. 1999; review Hennet 2002).
Reaction - small molecule participants:
UDP [Golgi lumen]
Type 1 chain [Golgi lumen]
GlcNAc-β1,3-Gal-R [Golgi lumen]
UDP-Gal [Golgi lumen]
Reactome.org reaction link: R-HSA-9603989
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Reaction input - small molecules:
GlcNAc-beta1,3-Gal-R
UDP-alpha-D-galactose(2-)
Reaction output - small molecules:
UDP(3-)
beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-alpha-D-Gal-yl group
Reactome.org link: R-HSA-9603989