Reaction: ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG
- in pathway: Lewis blood group biosynthesis
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6), located on the Golgi membrane, mediates the transfer of sialic acid (Neu5Ac) to Type 1 monosialylgalactosylgloboside (Type 1 MSGG) to form Type 1 disialylgalactosylgloboside (Type 1 DSGG), the precursor for disialyl-Lewis A antigen (Senda et al. 2007). ST6GALNAC6 and DSGG are found in proximal tubule epithelial cells in normal kidney tissues and are both downregulated in renal cancer cell lines and cancer tissues (Senda et al. 2007).
Reaction - small molecule participants:
CMP [Golgi lumen]
Type 1 DSGG [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
Type 1 MSGG [Golgi lumen]
Reactome.org reaction link: R-HSA-9603991
======
Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
Type 1 monosialylgalactosylgloboside
Reaction output - small molecules:
cytidine 5'-monophosphate(2-)
Type 1 disialyl-paragloboside
Reactome.org link: R-HSA-9603991