Reaction: AKT1 phosphorylates NOTCH4
- in pathway: Negative regulation of NOTCH4 signaling
Recombinant human AKT1 phosphorylates recombinant human NICD4 on four AKT-target sites conserved in primates: S1495, S1847, S1865 and S1917 (Ramakrishnan et al. 2015).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9604328
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9604328