Reaction: SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters
- in pathway: Pre-NOTCH Transcription and Translation
Based on studies in mice, SIRT6 deacetylates H3 histones on lysine residue 10 (removing the H3K9Ac epigenetic mark) at promoters of NOTCH1 and NOTCH4 genes (Liu et al. 2017).
Reaction - small molecule participants:
2'-O-acetyl-ADP-ribose [nucleoplasm]
NAD+ [nucleoplasm]
Reactome.org reaction link: R-HSA-9604829
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
2''-O-acetyl-ADP-D-ribose
Reactome.org link: R-HSA-9604829