Reaction: ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG
- in pathway: Lewis blood group biosynthesis
The alpha-2,3-sialyltransferases ST3GAL3,4 and 6 (Kitagawa & Paulson 1993, Okajima et al. 1999, Kitagawa & Paulson 1994) located on the Golgi membrane, mediate the transfer of sialic acid (Neu5Ac, N-acetylneuraminic acid) in an α2,3 linkage to the terminal galactose of Gal-beta-1,4-GlcNAc- sequences found on glycoproteins and glycolipids to form Type 2 monosialylgalactosylgloboside (Type 2 MSGG).
Increased sialylation has been associated with malignant transformation and metastasis. ST3GAL6 is highly expressed in patients with multiple myeloma (MM). Knockdown of ST3GAL6 has been shown to prolong survival in mice (Glavey et al. 2014).
Increased sialylation has been associated with malignant transformation and metastasis. ST3GAL6 is highly expressed in patients with multiple myeloma (MM). Knockdown of ST3GAL6 has been shown to prolong survival in mice (Glavey et al. 2014).
Reaction - small molecule participants:
CMP [Golgi lumen]
Type 2 MSGG [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
Type 2 chain [Golgi lumen]
Reactome.org reaction link: R-HSA-9605600
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Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
alpha-D-Gal-(1->3)-alpha-D-GlcNAc-(1->4)-D-Gal-yl group
Reaction output - small molecules:
cytidine 5'-monophosphate(2-)
Type 2 monosialylgalactosylgloboside
Reactome.org link: R-HSA-9605600