Reaction: FUT3 transfers Fuc to Type 1 DSGG to form dsLeA
- in pathway: Lewis blood group biosynthesis
The FUT3 gene (originally named the Le gene) expresses galactoside 3(4)-L-fucosyltransferase present on the Golgi membrane. FUT3 catalyses the α1,4 and α1,3 addition of fucose to Type 1 and Type 2 oligosaccharide chains respectively, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the subterminal N-acetylglucosaminyl (GlcNAc) residue of Type 1 disialylgalactosylgloboside (Type 1 DSGG) in an α1,4 linkage forms the disialyl-Lewis A antigen (dsLeA).
Reaction - small molecule participants:
GDP [Golgi lumen]
dsLeA [Golgi lumen]
Type 1 DSGG [Golgi lumen]
GDP-Fuc [Golgi lumen]
Reactome.org reaction link: R-HSA-9605644
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Reaction input - small molecules:
Type 1 disialyl-paragloboside
GDP-L-fucose
Reaction output - small molecules:
GDP(3-)
disialyl-Lewis A antigen
Reactome.org link: R-HSA-9605644