Reaction: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
- in pathway: Frs2-mediated activation
Downstream of NGF stimulation, activated BRAF phosphorylates MAP2K1 and MAP2K2 (MEK1 and MEK2) at the endosome, leading to sustained MAPK signaling (York et al, 1998; Kao et al, 2001; reviewed in Huang and Reichardt, 2003; Reichardt, 2006).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9610153
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9610153