Reaction: HCMV Binds Host Cell Receptor - Endocytic Pathway
- in pathway: HCMV Early Events
Viral attachment and penetration of Human Cytomegalovirus (HCMV) occurs either via direct HCMV fusion with the cell membrane or via endocytosis. The endocytic mechanism occurs with cell types including endothelial and epithelial cells, where the pentameric viral protein complex, gH:gL:p128:p130:p131A, facilitates entry.
Reaction - small molecule participants:
HSPG [plasma membrane]
Reactome.org reaction link: R-HSA-9610867
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Reaction input - small molecules:
heparan sulfate proteoglycan
Reaction output - small molecules:
Reactome.org link: R-HSA-9610867