Reaction: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates
- in pathway: NGF-independant TRKA activation
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. After binding to Ade-Rib:ADORA2A, NTRK1 and NTRK2 autophosphorylate at 5 tyrosine residues.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9613023
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9613023