Reaction: Unwinding of DNA for the Nascent Transcript: Second Transition
- in pathway: RNA Polymerase II Promoter Escape
The human BTF2 basic transcription factor (also called TFIIH), is required for class1 gene transcription of the second round of transcripts. TFIIH has an adenosine triphosphate-dependent DNA helicase activity. The helicase activity is closely associated with the multi-subunit BTF2/TFIIH transcription factor which also has a CTD protein kinase activity.
Reaction - small molecule participants:
AMP [nucleoplasm]
PPi [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-9613494
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
Reactome.org link: R-HSA-9613494