Reaction: Unwinding of DNA for the nascent HIV-1 transcript
- in pathway: RNA Polymerase II HIV Promoter Escape
The human BTF2 basic transcription factor (also called TFIIH), is required for class1 gene transcription of HIV transcripts. TFIIH has an adenosine triphosphate-dependent DNA helicase activity. The helicase activity is closely associated with the multi-subunit BTF2/TFIIH transcription factor which also has a CTD protein kinase activity.
Reaction - small molecule participants:
PPi [nucleoplasm]
NTP [nucleoplasm]
Reactome.org reaction link: R-HSA-9613498
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Reaction input - small molecules:
nucleoside 5'-triphoshate(4-)
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-9613498