Reaction: Mg2+ binds GRIN1:GRIN2 NMDA receptors
The pore of the NMDA receptor is blocked by binding of Mg2+ ions. The strength of the block depends on the subunit composition of the NMDA receptor, as both the GluN1 (GRIN1, NR1) subunit and GluN2 (GRIN2, NR2) subunits interact with Mg2+ (Nowak et al. 1984, Mayer et al. 1984, Wollmuth et al. 1998, Vargas-Caballero and Robinson 2004, Siegler Retchless et al. 2012, Schwartz et al. 2012, Clarke et al. 2013, reviewed by Iacobucci and Popescu 2017).
Reaction - small molecule participants:
Mg2+ [extracellular region]
Reactome.org reaction link: R-HSA-9614185
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Reaction input - small molecules:
magnesium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-9614185