Reaction: Activation of Latent HCMV Genome
- in pathway: HCMV Early Events
A cell containing a repressed or latent Human Cytomegalovirus (HCMV) genome sits quietly carrying on its normal cellular functions. The HCMV silenced HCMV geneome can be activated by a number of celluar events or state changes. Reactivation of HCMV lytic infection is correlated to changes in histone modifications around the MIEP promoter resulting in a new chromatin structure conducive to transcriptional activity. These changes are intimately linked with cell differentiation, a phenomenon known to reactivate latent virus in vivo.
Reaction - small molecule participants:
CoA-SH [nucleoplasm]
Ac-CoA [nucleoplasm]
Reactome.org reaction link: R-HSA-9614810
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-9614810