Reaction: ROS oxidize FOXO4 cysteine residues
Reactive oxygen species (ROS) oxidize cysteine residue(s) of FOXO4. There are five cysteine residues in FOXO4, of which two residues, C31 (corresponds to C27 in mouse Foxo4) and C481 (corresponds to C477 of mouse Foxo4) are conserved in other FOXO family members. Oxidation of C481 of FOXO4 has the most significant functional implications (Dansen et al. 2009).
Reaction - small molecule participants:
ROS [nucleoplasm]
Reactome.org reaction link: R-HSA-9617660
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Reaction input - small molecules:
reactive oxygen species
Reaction output - small molecules:
Reactome.org link: R-HSA-9617660