Reaction: CAMKK2 phosphorylates AMPK
- in pathway: Activation of AMPK downstream of NMDARs
Activated CAMKK2 (CaMKK-beta) phosphorylates the alpha subunit of AMP-activated kinase (AMPK). The CAMKK2 target site is evolutionarily conserved in two AMPK-alpha isoforms and corresponds to threonine 183 (T183) in PRKAA1 (AMPK-alpha1) and threonine 172 (T172) in PRKAA2 (AMPK-alpha2).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9619478
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9619478