Reaction: AMPK phosphorylates MAPT
- in pathway: Activation of AMPK downstream of NMDARs
AMPK, activated by CAMKK2-mediated phosphorylation, phosphorylates MAPT (Tau) on serine residues S262, S356 and S396. AMPK-mediated phosphorylation changes microtubule binding properties of MAPT and is involved in development and maintenance of dendritic spines and synaptotoxicity of beta-amyloid oligomers (Thornton et al. 2011, Mairet-Coello et al. 2013).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9619515
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9619515