Reaction: RSKs autophosphorylate
- in pathway: RSK activation
Upon phosphorylation by activated ERKs, ribosomal S6 kinases (RSKs) autophosphorylate on conserved serine residue in the linker region (S380 in RPS6KA1) and a conserved threonine residue at the C-terminal ERK-docking domain (T732 in RPS6KA1) (Dalby et al. 1998, Roux et al. 2003). Autophosphorylation at the ERK-docking domain regulates binding to ERK and duration of RSK activity (Roux et al. 2003).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9620004
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9620004