Reaction: Initiation of HCMV DNA Replication
- in pathway: HCMV Late Events
DNA synthesis occurs in the nucleus and relies on a core set of virus-coded proteins composed of replication fork machinery that work together to promote replication initiation on the oriLyt region. DNA synthesis initiates in the vicinity of oriLyt as soon as essential virus encoded proteins appear, producing high molecular weight replication intermediates. Onset of viral DNA synthesis licenses transcription of a subset of the late class (L) of viral genes, many of which encode proteins that take part in virion assembly.
Reaction - small molecule participants:
dNTP [nucleoplasm]
Reactome.org reaction link: R-HSA-9624033
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Reaction input - small molecules:
2'-deoxyribonucleoside triphosphate
Reaction output - small molecules:
Reactome.org link: R-HSA-9624033