Reaction: Cys-sulfenyl chloride is converted to Cys-sulfenic acid
Thiol-containing cysteine (Cys) residues are reactive with species of the oxidative burst. Hypochlorous acid (HOCl) leads to chlorination of Cys residues forming Cys-sulfenic acid (Cys-SOH) intermediates, which can either form a disulfide with an adjacent thiol or be further oxidized by HOCl to generate Cys- sulfinic and Cys-sulfonic acids sequentially (Peskin AV & Winterbourn CC 2001; Hawkins CL et al. 2003; Paulsen CE & Carroll KS 2013; Winterbourn CC & Kettle AJ 2013). Disulfides function as redox switches to control protein activity and protect thiol groups against overoxidation to Cys-sulfinic and -sulfonic acids (Paulsen CE & Carroll KS 2013).
Reaction - small molecule participants:
Cl- [phagocytic vesicle lumen]
H+ [phagocytic vesicle lumen]
H2O [phagocytic vesicle lumen]
Reactome.org reaction link: R-HSA-9625540
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Reaction input - small molecules:
water
Reaction output - small molecules:
chloride
hydron
Reactome.org link: R-HSA-9625540