Reaction: Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine
Myeloperoxidase (MPO)-produced hypochlorous acid (HOCl) reacts with N-terminal amino acids and lysine (Lys) residues of proteins contained within phagosomes to form protein chloramines and dichloramines (Chapman ALP et al. 2002; Green JN et al. 2017). These species decompose to yield chlorimines, aldehydes, and the inorganic gases ammonia monochloramine (NH2Cl) and ammonia dichloramine (NHCl2) (Hazen S et al. 1998; Coker MS et al. 2008; Green JN et al. 2017). Cytotoxic NH2Cl and NHCl2 may contribute to killing of ingested bacteria (Coker MS et al. 2008; Green JN et al. 2017).
Reaction - small molecule participants:
H2O [phagocytic vesicle lumen]
HOCl [phagocytic vesicle lumen]
Reactome.org reaction link: R-HSA-9625904
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Reaction input - small molecules:
hypochlorous acid
Reaction output - small molecules:
water
Reactome.org link: R-HSA-9625904