Reaction: SIRT1 deacetylates FOXO1
A histone deacetylase SIRT1 deacetylates FOXO1. Deacetylation increases FOXO1-mediated upregulation of SOD2 and CDKN1B (Diatoku et al. 2004). SIRT-dependent deacetylation leads to retention of FOXO1 in the nucleus (Frescas et al. 2005).
Reaction - small molecule participants:
NAM [nucleoplasm]
2'-O-acetyl-ADP-ribose [nucleoplasm]
NAD+ [nucleoplasm]
Reactome.org reaction link: R-HSA-9626962
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
2''-O-acetyl-ADP-D-ribose
Reactome.org link: R-HSA-9626962