Reaction: CASP9 is phosphorylated at T412
- in pathway: Regulation of the apoptosome activity
Phosphorylation of caspase 9 (CASP9) may contribute to the suppression of apoptosis. A major inhibitory phosphorylation site in CASP9 is Thr412, which forms part of a Thr‑Pro motif (Allan LA & Clarke PR 2007; Martin MC et al. 2008). This motif is targeted by multiple proline‑directed kinases such as ERK1/2 in response to extracellular growth/survival signals or CDK1‑cyclin B1 during mitosis (Allan LA et al. 2003; Allan LA & Clarke PR 2007; Martin MC et al. 2008). Thr412 is also phosphorylated by DYRK1A, which regulates apoptosis during development (Seifert A et al. 2008).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9627089
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9627089