Reaction: NEIL3 cleaves 5-guanidinohydantoin
- in pathway: Cleavage of the damaged purine
NEIL3 cleaves oxidatively damaged guanin in the form of 5-guanidinohydantoin with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing and abasic site (AP site) (Liu et al. 2010, Krokeide et al. 2013).
Reaction - small molecule participants:
Gh [nucleoplasm]
Reactome.org reaction link: R-HSA-9629470
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Reaction input - small molecules:
Reaction output - small molecules:
5-guanidinohydantoin
Reactome.org link: R-HSA-9629470