Reaction: NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA
- in pathway: Cleavage of the damaged purine
NEIL3 cleaves oxidatively damaged guanine in the form of spiroiminodihydantoin (Sp) form telomeric DNA, leaving an abasic (AP) site (Zhou et al. 2013).
Reaction - small molecule participants:
Sp [nucleoplasm]
Reactome.org reaction link: R-HSA-9629483
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Reaction input - small molecules:
Reaction output - small molecules:
spiroiminodihydantoin
Reactome.org link: R-HSA-9629483