Reaction: NEIL3 cleaves spiroiminodihydantoin
- in pathway: Cleavage of the damaged purine
NEIL3 cleaves oxidatively damaged guanine in the form of spiroiminodihydantoin (Sp) with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing an abasic (AP) site (Krokeide et al. 2013). The preference of NEIL3 for ssDNA was structurally explained using mouse Neil3 (Liu et al. 2013).
Reaction - small molecule participants:
Sp [nucleoplasm]
Reactome.org reaction link: R-HSA-9629492
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Reaction input - small molecules:
Reaction output - small molecules:
spiroiminodihydantoin
Reactome.org link: R-HSA-9629492